Zonal Differences in the Deformation Characteristics of the Cartilage Chondron
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An axisymmetric boundary element model for determination of articular cartilage pericellular matrix properties in situ via inverse analysis of chondron deformation.
The pericellular matrix (PCM) is the narrow tissue region surrounding all chondrocytes in articular cartilage and, together, the chondrocyte(s) and surrounding PCM have been termed the chondron. Previous theoretical and experimental studies suggest that the structure and properties of the PCM significantly influence the biomechanical environment at the microscopic scale of the chondrocytes with...
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BACKGROUND Dedifferentiation of chondrocytes remains a major problem for cartilage tissue engineering. Chondrocytes loss differentiated phenotype in in vitro culture that is undesired for repair strategies. The chondrocyte is surrounded by a pericellular matrix (PCM), together forming the chondron. PCM has a positive effect on the maintenance of chondrocyte phenotype during culture in compar...
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Stress relaxation and structural analysis were used to investigate the zonally differentiated microstructural response to compression of the integrated cartilage-on-bone tissue system. Fifteen cartilage-on-bone samples were divided into three equal groups and their stress relaxation responses obtained at three different levels of axial compressive strain defined as low (~20%), medium (~40%) and...
متن کامل0105 - Cell Deformation within Isolated Chondrons Compressed in Agarose Constructs
Introduction: Chondrocytes within articular cartilage are surrounded by a complex pericellular microenvironment which, together with the cell, is termed the chondron. The mechanical and physicochemical properties of the chondron matrix will undoubtedly influence the metabolism of the chondrocytes and their response to joint loading. The aim of the present study was to examine cell morphology in...
متن کاملImportance of Floating Chondrons in Cartilage Tissue Engineering
BACKGROUND Dedifferentiation of chondrocytes remains a major problem for cartilage tissue engineering. Chondrocytes loss differentiated phenotype in in vitro culture that is undesired for repair strategies. The chondrocyte is surrounded by a pericellular matrix (PCM), together forming the chondron. PCM has a positive effect on the maintenance of chondrocyte phenotype during culture in compariso...
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تاریخ انتشار 2006